Science
Genetic medicine needs a paradigm shift.
The promise of genetic medicine to cure diseases is falling short because:
Limited Biodistribution
Payload Size Limitations
Immunogenic
Non-Redosable
Material-Related Toxicities
Complex & Costly CMC
We are working to address all of these challenges.
Technology
Using ultrasound-mediated delivery
SonoThera is developing a proprietary, nonviral, non-invasive, immune stealth approach which enables:
Broad, Highly Targeted Biodistribution
Our proprietary RIPPLE™ technology enables highly targeted biodistribution to nearly any organ in the body without unwanted off-target delivery.
Delivery of Diverse Genetic Medicines Without Size Restriction
RIPPLE™ enables delivery of DNA and/or RNA constructs of unlimited size, expressing full-length transgenic proteins; gene editors, siRNAs and ASOs.
In a Redosable Manner
RIPPLE™ is redosable, maintaining stable, personalized therapeutic gene expression levels over time.
Designed to be Safe, Well-Tolerated and Cost-Effective
RIPPLE™ avoids the immunogenicity and material-related toxicity of nonviral and viral vectors (AAVs and LNPs).
RIPPLE™
SonoThera exclusively holds the foundational IP on RIPPLE™ technology enabling safe, efficient, immune stealth and uniform biodistribution.
RIPPLE™
(Remote Induction of Pulsed Pressure Lateral to Energy)
Pipeline
SonoThera is advancing its therapeutic programs in several areas: muscle, kidney, liver, heart, and CNS.
We have presented data publicly specific to the following diseases:
Duchenne Muscular Dystrophy (DMD) and Limb-girdle muscular dystrophies (LGMD).
X-linked Alport Syndrome (x-LAS) and Autosomal Dominant Polycystic Kidney Disease (ADPKD).
Discovery pipeline pursuing genetic diseases in the heart, adipose tissue and brain.
We are poised to initiate our first human clinical trial in 2027 with a pipeline of several INDs following, supporting a steady cadence of clinical data through 2028.
Published Research
Learn more about successful proof of concept studies on the topic of ultrasound-mediated genetic medicine delivery.